In animal reproduction studies, codeine administered because of the oral route to pregnant rats in the course of the period of organogenesis increased resorptions and diminished fetal weights at a dose approximately 26 situations the utmost advised human dose (MRHD) inside the existence of maternal toxicity (see Facts). For pregnant mice and rats that received promethazine at doses 0.05 to 6 times the MRHD, through many periods of gestation, there have been findings of increased fetal resorptions and skeletal fragility, lessened pup body weight, and developmental delays of pups (see Data). Determined by the animal data, suggest pregnant Gals on the possible threat to a fetus.
If you believe There's been an overdose, contact your poison Manage center or get professional medical treatment straight away. Be ready to inform or demonstrate what was taken, simply how much, and when it took place. How do I keep and/or toss out Promethazine and Codeine?
All medicine might trigger side effects. However, Lots of people don't have any Unintended effects or only have small Uncomfortable side effects. Phone your medical professional or get health care assist if any of these Uncomfortable side effects or almost every other Unintended effects trouble you or usually do not go away: Feeling sleepy. Dizziness. Feeling anxious and excitable. Constipation.
Codeine may well boost the neuromuscular blocking action of skeletal muscle mass relaxants and produce an increased diploma of respiratory despair.
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Do not improve your dose or use this merchandise extra often or for for a longer time than prescribed. Your issue will not likely improve any quicker, along with your chance of Unintended effects will maximize.
This medication may have sugar and/or Alcoholic beverages. Caution is suggested When you have diabetic issues, alcohol dependence, or liver ailment. Ask your health practitioner or pharmacist about employing this solution securely.
Do not flush down a rest room or pour down a drain Unless of course you are advised to do so. Verify with your pharmacist When you have questions on The easiest way to throw out medications. There might be drug consider-again systems in your area. Purchaser Information Use and Disclaimer
Hold a list of every one of the products you use (which includes prescription/nonprescription medicine and herbal products) and share it with your doctor and pharmacist. Usually do not commence, cease, or change the dosage of any medicines without your physician's approval.
To help you avoid withdrawal, your physician may decreased your dose slowly and gradually. Withdrawal is more probable In case you have utilized this medication Promethazine With Codeine for many years (quite a lot of months) or in large doses. Convey to your medical professional or pharmacist immediately When you've got withdrawal.
Promethazine has an elimination 50 %-lifetime of ten-fourteen hrs, with excretion of metabolites showing while in the urine and feces. The sulfoxides of promethazine and N-demethylpromethazine are definitely the predominant metabolites showing up within the urine.
When your indicators or health conditions usually do not recuperate or should they come to be worse, contact your doctor. Will not share your medications with others and do not consider anyone else's prescription drugs. This medication comes with an additional affected person actuality sheet referred to as a Medication Guideline. Go through it with treatment. Read through it once more every time promethazine and codeine is refilled.
Codeine was not mutagenic within the in vitro bacterial reverse mutation assay or clastogenic within the in vitro Chinese hamster ovary (CHO) mobile chromosomal aberration assay.
are Expecting or strategy to be Expecting. PROMETHAZINE WITH CODEINE ORAL Answer can damage your unborn toddler. See “What's The key info I need to find out about PROMETHAZINE WITH CODEINE ORAL Alternative?” are breastfeeding or plan to breastfeed. Codeine passes into your breast milk and can result in really serious Negative effects in your baby which includes amplified sleepiness, respiration problems (respiratory melancholy), and Loss of life. It is far from recognized if promethazine can pass into your breast milk.